Study Found Drug Combination Led to Worsening Sexual Health

Study found Drug Combination led to worsening of sexual health survey results compared to placebo

Renal & Urology News (11/24, Charnow) reports on a study (11/16) published in BJU International promising to "Put into context the erectile and ejaculatory dysfunction adverse events (AEs) reported spontaneously in earlier studies of 5-alpha-reducanse inhibitors (SARIs)."

The study was based on the Men's Sexual Health Questionnaire on patients who received "a fixed-dose combination of dutasteride 0.5 mg and tamsulosin 0.4 mg" and who had "lower urinary tract symptoms (LUTS) secondary to denign prostatic hyperplasia (BPH)." They found that compared to placebo, "the drug combination arm had a significant decrease (worsening) in total MSHQ score" as well as "the ejaculation (-7.5 vs -0.6)  and satisfaction domains (-0.6 vs +0.3)." The study included "489 patients with BPH-related LUTS: 253 in the combination arm and 246 in the placebo arm."

This is one of the many reasons why I have never routinely combined alpha blockers and 5-alpha reductase inhibitors, and why I have always disliked 5-alpha reductase inhibitors in general! -  Dr. Potts

Read Dr. Pott's blog: "When will MEN finally be treated as well as Chickens!?"